Advantages Of Phase Contrast: A Few Examples

inCiTe™ is a world-first phase-contrast benchtop micro-CT. Using KA Imaging patented technology, this x-ray microscope excels at imaging materials that have poor x-ray absorption, such as biomaterials, polymer composites and other low-density samples. inCiTe is also the first commercial micro-CT to utilize BrillianSe™, the highest spatial resolution direct conversion X-ray detector in the world for hard x-rays, that allows for true unmagnified resolution down to 8μm.

Why phase-contrast?

When an object is placed in front of an x-ray source, the shadows, or projections, of the object can be captured by a detector in the background. Computed tomography, also known as CT, is the process of reconstructing an image representation of the object from its x-ray projections using computer algorithms.

The primary advantage of the phase-contrast paradigm is that when an object presents poor conventional absorption-contrast (e.g. soft biological tissue or other low-density materials such as polymers), contrast can instead be generated with higher sensitivity using phase-contrast techniques.

inCiTe™ achieves phase-contrast directly by free-space propagation of the X-ray beam, transforming X-ray phase changes due to the object into X-ray intensity variations at the detector.

The result is an image with much more detail, which wouldn’t be possible using conventional CT techniques.

Watch the video below to see some images and the results of inCiTe.


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2019 at a glance

“We set a number of very ambitious, stretch goals for 2019 and incredibly, accomplished most of them”, said Dr. Karim S Karim, CTO at KA Imaging.  “I’m very happy and proud of the entire KA family and how well they work with and support each other”, he continued.

A family that has continuously grown. In 2019, 10 new people joined KA Imaging, sharing their expertise in different areas, such as Engineering, Finance and Business Development. The number of employees is now 58% higher than in 2016. “We have a great team of dedicated people who are interested in learn and developing good products”, explained Amol Karnick, CEO at KAI. “The team has grown this year to included additional skill set including hardware and software design”, he said.

A year to celebrate

2019 was full of highlights. The company exhibited at 6 conferences and visited several others, having traveled more than 10,000 km around the globe.

KA Imaging’s inCiTe™ micro CT had its commercialization started and the first unit was delivered at the National Research Council Canada. At MRS, the technology was introduced to researchers, along with BrillianSe™, the world’s highest spatial resolution direct conversion X-ray detector for hard X-ray. Christopher Scott, an engineer leading the inCiTe™ and BrillianSe™ product development, had a poster presentation to talk about the technology.

The dual-energy single exposure flat panel detector Reveal™ was launched at RSNA and has sparked interest in the industry. Engineer Sebastian Maurino had a talk during the conference and gave more details about the technology. Representing KA Imaging, his abstract received the Roadie Award from AuntMinnie.  “Our clinical trial with patient data has been excellent as well as it shows tangibly the benefits of KA Imaging’s efforts”, celebrated Dr. Karim.

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Amol Karnick, CEO (M.Eng, BASc)
Amol is a seasoned executive in the medical device industry. His experience covers the whole spectrum; from start-ups (Ultrasonix, Sentinelle Medical, Ventripoint) to large OEMs (GE Healthcare). Entering into the profession with a Bachelors in Engineering from UW and a Masters in Electrical Engineering from McGill, Amol spent 20 years in the medical imaging space to become a leader of multidisciplinary teams (sales, engineering and operations). Amol is now poised to steer KA Imaging into a position of global leadership.
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Karim S. Karim, CTO
(PhD, PEng, MBA)
A professor of Electrical and Computer Engineering at the University of Waterloo, Dr.Karim is a distinguished academician known for pioneering and commercializing large area current mode active pixel sensor technology that is now used in bio-metric fingerprint readers for mobile phones. With 20 years of experience in designing and prototyping large area digital imagers, Dr.Karim has been instrumental in raising over $12 million in research funding. A full member of the American Association of Physicists in Medicine (AAPM), Dr.Karim is also an IEEE distinguished lecturer.
Ken Green, CFO (CPA, MBA)
Ken has a strong background in finance, accounting and strategic business operations developed from several years of work experience in the financial services industry. Ken gained valuable experience working for a number of major Canadian and global firms such as PricewaterhouseCoopers, Royal bank of Canada, Bank of Montreal and Scotia Bank. However, his most valuable learning experiences come from working with many small businesses including start-ups and established businesses helping them manage their accounting and finance operations. Ken is a Chartered Professional Accountant and has an MBA from the Schulich Business School.
Sina Ghanbarzadeh, Co-Founder
(MSc, PhD*)
Sina is the co-founder and the lead of the design team at KA Imaging Inc. He brings over 7 years of experience in design and characterization of imaging detectors to the KA Imaging Inc. He has designed the state of the art imaging detector prototype and currently leading the design team at both device and system level. Sina holds a Masters in Science degree in Electrical Engineering from the University of Waterloo and is also working towards his PhD at University of Waterloo.
Joan Medley, Quality Regulatory Expert (ISO 13485)
Joan began her career as a Medical Radiation Technologist at Sunnybrook Health Sciences, specializing in general and trauma radiography, CT scanning, angiography, heart catheterizations and fulfilled the role of clinical instructor. She has co-authored a Quality & Regulatory college course providing outline, course content and learning objectives. With over 2 decades of experience as a Quality Assurance (QA) Manager and Director, Joan has led medical device manufacturers through ISO registration and managing Quality Management systems. Certified as an ISO 13485 Lead Auditor, Joan currently provides contract services for a certification body.
Jill Zappitelli, Human Resources Consultant (CHRL)
An experienced and accredited Human Resource Professional and Program/Project Manager, Jill’s rich expertise and national and international experience in every facet of Human Resources affords her the distinction of being one of the most sought-after HR professionals in the region. As a member of the HRPA Board of Directors, her CHRL designation combined with a Business Administration Management Diploma from Conestoga College – Jill brings a genuine level of confidence to any organization that finds itself without some HR guidance. Creating and implementing authentic and effective HR solutions to solve an array of employee challenges have been Jill’s signature for several years with companies ranging from SunLife Financial to Blackberry, to non-profits such as Trellis Mental Health. Now, as a consultant to Waterloo’s emerging businesses and tech community, Jill has been delivering relevant and meaningful solutions to scale – be it program level or simply getting the right advice.
Ako S. Williams, Vice President
Ako Williams is Vice President, General Counsel and Corporate Secretary of Ushio America, Inc., which is a U.S. subsidiary of Ushio Inc. in Tokyo, Japan. Ushio is a leading provider of light sources and solutions for a wide variety of applications, including medical imaging and illumination, scientific, semiconductor, entertainment, horticulture, and architectural applications. A seasoned global enterprise executive with a strategic problem solving approach, Ako oversees Ushio America’s legal, regulatory compliance, risk management, and corporate governance matters. Previously, she was an Assistant General Counsel and Compliance Officer of Christie Digital Systems USA, Inc. (an Ushio group company) and an Assistant General Counsel of a leading home healthcare provider in the U.S. She holds a B.S. (highest distinction) from Northwestern University and a J.D. from Loyola University Chicago School of Law.
(B.S, J.D)
Ian Cunningham (BSc, MSc, PhD)
Dr. Ian Cunningham is a professor and scientist at the Robarts Research Institute at The University of Western Ontario and physicist at London Health Sciences Centre. He directs a research team of graduate students and post-doctoral fellows that are investigating new ways of acquiring and displaying medical images using digital radiography and computed tomography for improved health care.
James Wei (VP, Business Development )
James earned an M.Sc. at UW Canada and a Ph.D. at INSA Lyon France in RF engineering before starting his career in mixed signal development for the telecom industry. An Executive MBA degree from the University of Zurich in Switzerland charted his course into leadership roles in business development, where his specialty lies in international sales and marketing for tech start-ups. James brings a decade of experience to KA Imaging in new product market entry, global distribution channel management, and Asian subsidiary setups. It is James who will take KA Imaging to the forefront of the overseas marketplace.
Susan Horton (BA, MA, PhD)
Working for the World Bank got Susan interested in health and economics. Dr. Horton then proceeded to work at the International Centre for Diarrheal Disease Research in Bangladesh while writing her thesis. She has worked or taught in about 25 low and middle income countries, on topics ranging from labour markets, women's participation, benefits and costs of micronutrient interventions, and currently costs and benefits of breastfeeding, cost and cost-effectiveness of cancer interventions, and disease control priorities in low and middle income countries. Currently, Dr.Horton is working on the Disease Control Priorities project and in the past, worked on research projects with the World Bank, FAO, WHO, UNICEF, Copenhagen Consensus, etc.
Ruben Romero (CPA, CMA)
Ruben has a strong background in finance, accounting and strategic business operations from several years of work experience in various industries. Prior to joining KA Imaging's team, Ruben gained valuable experience working for Canadian and Global firms such as Class 1 Inc. and Bimbo Bakeries. Ruben has been a Chartered Professional Accountant and Certified Management Accountant for over ten years.